Myeloid Leukemia: Methods and Protocols
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Book Overview
A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
Format:Paperback
Language:English
ISBN:1607614561
ISBN13:9781607614562
Release Date:November 2020
Publisher:Humana
Length:307 Pages
Weight:1.00 lbs.
Dimensions:0.6" x 7.7" x 9.1"
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